There are no mutants in 616 (that we know of) besides Ms. Marvel lol. Deadpool and Wolverine are not in the 616 by the end of the filmDeadpool was talking about the Avenger abd talking to Happy, both if which are in the MCU's 616 universe.
I think that was more of a throwaway line in Ms Marvel.
And in the Marvels that was a completely different universe we seen Beast in.